{
  "creator": [
    "Jiang, Huan",
    "Rehm, Jürgen",
    "Probst, Charlotte",
    "Tran, Alexander",
    "Lange, Shannon",
    "Llamosas-Falcón, Laura"
  ],
  "date": [
    "2025-06-30"
  ],
  "description": [
    "Dose-response relationships between continuous risk factors and disease outcomes are necessary for understanding the risks related to different levels of exposure. Dose-response risk curves can lead to more targeted public health messaging, prevention efforts, and policy implementation. Meta-analyses are often used to combine statistical results from different studies and can be used to model dose-response relationships. However, several challenges are encountered when performing dose-response meta-analysis, such as having heterogeneous reference categories, inconsistent measures of risk, and determining the most accurate shape of the curve. In this paper, we propose a three-step process for estimating dose-response relationships via meta-analysis, which involves: 1) harmonizing the measures of risk, 2) homogenizing the reference category, and 3) selecting meta-regression models. We use data obtained from a systematic review on the dose-response relationship between alcohol consumption and the risk of chronic liver disease to provide an example of the proposed process."
  ],
  "format": [
    "application/pdf",
    "text/html",
    "text/xml"
  ],
  "identifier": [
    "https://meth.psychopen.eu/index.php/meth/article/view/14733",
    "10.5964/meth.14733"
  ],
  "language": [
    "eng"
  ],
  "publisher": [
    "PsychOpen GOLD / Leibniz Institut for Psychology (ZPID)"
  ],
  "relation": [
    "https://meth.psychopen.eu/index.php/meth/article/view/14733/14733.pdf",
    "https://meth.psychopen.eu/index.php/meth/article/view/14733/14733.html",
    "https://meth.psychopen.eu/index.php/meth/article/view/14733/14733.xml"
  ],
  "rights": [
    "Copyright (c) 2025 Huan Jiang, Jürgen Rehm, Charlotte Probst, Alexander Tran, Shannon Lange, Laura Llamosas-Falcón",
    "https://creativecommons.org/licenses/by/4.0"
  ],
  "source": [
    "Methodology; Vol. 21 No. 2 (2025); 144-160",
    "1614-2241",
    "1614-1881",
    "10.5964/meth.v21i2"
  ],
  "subject": [
    "epidemiology",
    "dose response",
    "risk curves",
    "methodology",
    "dose-response meta-analysis"
  ],
  "title": [
    "A Practical Guide to Conducting Dose-Response Meta-Analyses in Epidemiology"
  ],
  "type": [
    "info:eu-repo/semantics/article",
    "info:eu-repo/semantics/publishedVersion",
    "Peer-reviewed Article"
  ]
}